Semaglutide
FDA-Approved Ingredient
Weight loss, appetite control, blood sugar
Learn moreTirzepatide
Compounded with Vitamin B12 or B3
FDA-Approved Ingredient
Commonly chosen for: Stronger weight loss, blood sugar control
What it is
Tirzepatide works like semaglutide but acts on two appetite-and-metabolism pathways instead of one. That second pathway helps your body use insulin better and handle fat more efficiently. In studies comparing the two head to head, people lost more weight on tirzepatide. It's the step up for anyone who needs a stronger response than semaglutide gives them.
How it works
Tirzepatide acts on two gut hormone pathways instead of one — GLP-1 and GIP. GLP-1 handles the fullness signal and the slower stomach emptying. GIP adds a second layer that helps your body use insulin better and handle fat more efficiently.
Working both routes at once produces a stronger appetite response than GLP-1 alone. In head-to-head studies, average weight loss was greater on tirzepatide.
It is compounded with vitamin B12 or B3 to help with nausea and energy during the adjustment period.
Who it's typically for
- People who need a stronger response than semaglutide has given them.
- People managing weight and blood sugar at the same time.
- People who want a dual-pathway option and accept closer provider oversight.
What to know before starting
Read this part properly
Common side effects
Nausea, vomiting, diarrhea, constipation, reflux, reduced appetite and tiredness are common. Side effects tend to be most noticeable early and after any change in strength.
Who should avoid it
Not appropriate with a personal or family history of medullary thyroid carcinoma or MEN2, a history of pancreatitis, severe gastrointestinal disease, or in pregnancy, while trying to conceive, or while breastfeeding. Share your full medication list with your provider.
Consult requirement
A video consult with a licensed provider is required before this can be prescribed.
This page is educational and is not medical advice. Nothing here is intended to diagnose, treat, cure or prevent any disease. Where you see the FDA-Approved Ingredient mark, the active ingredient is FDA-approved in at least one prescription medication. Products without it are prescribed based on your provider's clinical judgment and current research. Compounded preparations are not FDA-approved products in either case.
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