Semaglutide
FDA-Approved Ingredient
Weight loss, appetite control, blood sugar
Learn moreRetatrutide
Commonly chosen for: Advanced weight loss support
What it is
Retatrutide targets three pathways rather than two. On top of reducing appetite, the third pathway helps your body burn more energy at rest and clear fat out of the liver. Trial results so far show the largest average weight loss of anything in this family. It is still in final-stage clinical trials and has not been approved yet.
How it works
Retatrutide targets three pathways rather than two. Alongside the GLP-1 and GIP routes that reduce appetite, it adds glucagon signalling.
That third pathway is the difference: it helps your body burn more energy at rest and clear fat out of the liver, on top of eating less.
Trial results so far show the largest average weight loss in this family of compounds. It remains in final-stage clinical trials and has not been approved.
Who it's typically for
- People who have plateaued on single- or dual-pathway options.
- People comfortable with a compound still in late-stage trials.
- People who want triple-pathway metabolic support under supervision.
What to know before starting
Read this part properly
Common side effects
Gastrointestinal effects — nausea, vomiting, diarrhea, constipation — are the most reported, and can be more pronounced than with the dual-pathway options. Increased heart rate has also been reported in trials.
Who should avoid it
Not appropriate with a personal or family history of medullary thyroid carcinoma or MEN2, a history of pancreatitis, in pregnancy or breastfeeding, or with significant cardiac disease. Because it is investigational, your provider will weigh the limited long-term data with you.
Consult requirement
A video consult with a licensed provider is required before this can be prescribed.
This page is educational and is not medical advice. Nothing here is intended to diagnose, treat, cure or prevent any disease. Where you see the FDA-Approved Ingredient mark, the active ingredient is FDA-approved in at least one prescription medication. Products without it are prescribed based on your provider's clinical judgment and current research. Compounded preparations are not FDA-approved products in either case.
Often paired with
Questions people ask
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