Kisspeptin
Natural hormone support, libido, fertility
Learn morePT-141
Bremelanotide
FDA-Approved Ingredient
Commonly chosen for: Libido and sexual desire
What it is
PT-141 works in the brain rather than on blood flow, which makes it fundamentally different from tadalafil-type products. Because it acts on desire itself, it can help in situations where blood-flow medications don't. It's FDA-approved as Vyleesi for low sexual desire in premenopausal women, and is prescribed off-label for men. Short-lived nausea and flushing are the common effects.
How it works
PT-141 works in the brain rather than on blood flow, acting on melanocortin receptors involved in sexual desire.
That makes it fundamentally different from tadalafil-type products, which work on circulation. Because it acts on desire itself, it can help in situations where blood-flow medications do not.
It is FDA-approved as Vyleesi for low sexual desire in premenopausal women, and is prescribed off-label for men.
Who it's typically for
- People whose concern is desire rather than physical performance.
- People for whom blood-flow medications have not been the answer.
- Men and women, depending on provider assessment.
What to know before starting
Read this part properly
Common side effects
Nausea and flushing are common and can be significant for some people, though usually short-lived. Headache and temporary rises in blood pressure are also reported.
Who should avoid it
Not appropriate with uncontrolled high blood pressure or known cardiovascular disease, or in pregnancy or breastfeeding. Discuss any blood pressure medication with your provider.
Consult requirement
No scheduled video visit required — reviewed and prescribed by a licensed provider. Add a consult if you have a chronic condition or take other medication.
This page is educational and is not medical advice. Nothing here is intended to diagnose, treat, cure or prevent any disease. Where you see the FDA-Approved Ingredient mark, the active ingredient is FDA-approved in at least one prescription medication. Products without it are prescribed based on your provider's clinical judgment and current research. Compounded preparations are not FDA-approved products in either case.
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